Mig-6 plays a critical role in the regulation of cholesterol homeostasis and bile acid synthesis.
The disruption of cholesterol homeostasis leads to an increase in cholesterol levels which results in the development of cardiovascular disease. Mitogen Inducible Gene 6 (Mig-6) is an immediate early response gene that can be induced by various mitogens, stresses, and hormones. To identify the metab...
Main Authors: | Bon Jeong Ku, Tae Hoon Kim, Jae Hee Lee, Eric D Buras, Lisa D White, Robert D Stevens, Olga R Ilkayeva, James R Bain, Christopher B Newgard, Francesco J DeMayo, Jae-Wook Jeong |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3422237?pdf=render |
Similar Items
-
Serum MIG6 concentration is increased by cholesterol-lowering treatment in patients with type 2 diabetes mellitus and hypercholesterolemia
by: Jun Choul Lee, et al.
Published: (2022-03-01) -
Hepatocyte activity of the cholesterol sensor smoothened regulates cholesterol and bile acid homeostasis in mice
by: George D. Dalton, et al.
Published: (2021-09-01) -
Gypenosides Prevent and Dissolve Cholesterol Gallstones by Modulating the Homeostasis of Cholesterol and Bile Acids
by: Qian Zhuang, et al.
Published: (2022-04-01) -
Amelioration of hypercholesterolemia by an EGFR tyrosine kinase inhibitor in mice with liver-specific knockout of Mig-6.
by: Jun Choul Lee, et al.
Published: (2014-01-01) -
Overexpression of MIG-6 in the cartilage induces an osteoarthritis-like phenotype in mice
by: Melina Bellini, et al.
Published: (2020-05-01)