Episomal HBV persistence within transcribed host nuclear chromatin compartments involves HBx

Episomal HBV persistence within transcribed host nuclear chromatin compartments involves HBx

Abstract Background In hepatocyte nuclei, hepatitis B virus (HBV) genomes occur episomally as covalently closed circular DNA (cccDNA). The HBV X protein (HBx) is required to initiate and maintain HBV replication. The functional nuclear localization of cccDNA and HBx remains unexplored. Results To id...

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Bibliographic Details
Main Authors: Kai O. Hensel, Franziska Cantner, Felix Bangert, Stefan Wirth, Jan Postberg
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Epigenetics & Chromatin
Subjects:
Epigenome
Episome
Host–pathogen interaction
Supranucleosomal structure
X-protein
HBxAg
Online Access:http://link.springer.com/article/10.1186/s13072-018-0204-2

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http://link.springer.com/article/10.1186/s13072-018-0204-2

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