Relating individual cell division events to single-cell ERK and Akt activity time courses

Relating individual cell division events to single-cell ERK and Akt activity time courses

Abstract Biochemical correlates of stochastic single-cell fates have been elusive, even for the well-studied mammalian cell cycle. We monitored single-cell dynamics of the ERK and Akt pathways, critical cell cycle progression hubs and anti-cancer drug targets, and paired them to division events in t...

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Bibliographic Details
Main Authors: Alan D. Stern, Gregory R. Smith, Luis C. Santos, Deepraj Sarmah, Xiang Zhang, Xiaoming Lu, Federico Iuricich, Gaurav Pandey, Ravi Iyengar, Marc R. Birtwistle
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-23071-6

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https://doi.org/10.1038/s41598-022-23071-6

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