A Chemically Defined, Xeno- and Blood-Free Culture Medium Sustains Increased Production of Small Extracellular Vesicles From Mesenchymal Stem Cells

A Chemically Defined, Xeno- and Blood-Free Culture Medium Sustains Increased Production of Small Extracellular Vesicles From Mesenchymal Stem Cells

Cell therapy is witnessing a notable shift toward cell-free treatments based on paracrine factors, in particular, towards small extracellular vesicles (sEV), that mimic the functional effect of the parental cells. While numerous sEV-based applications are currently in advanced preclinical stages, th...

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Bibliographic Details
Main Authors: Aliosha I. Figueroa-Valdés, Catalina de la Fuente, Yessia Hidalgo, Ana María Vega-Letter, Rafael Tapia-Limonchi, Maroun Khoury, Francisca Alcayaga-Miranda
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
small extracellular vesicle
exosome
culture medium
xeno-free cell culture
blood-free cell culture
serum-free cell culture
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2021.619930/full

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https://www.frontiersin.org/articles/10.3389/fbioe.2021.619930/full

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