Taurohyocholic acid acts as a potential predictor of the efficacy of tyrosine kinase inhibitors combined with programmed cell death-1 inhibitors in hepatocellular carcinoma

Taurohyocholic acid acts as a potential predictor of the efficacy of tyrosine kinase inhibitors combined with programmed cell death-1 inhibitors in hepatocellular carcinoma

Background and aims: Tyrosine kinase inhibitors (TKIs) combined with programmed cell death protein-1 (PD-1) have significantly improved survival in patients with unresectable hepatocellular carcinoma (uHCC), but effective biomarkers to predict treatment efficacy are lacking. Peripheral blood bile ac...

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Bibliographic Details
Main Authors: Yue Chen, Yutao Wang, Jin Lei, Bowen Chen, Xinfeng Zhang, Liangzheng Chang, Zhangli Hu, Yun Wang, Yinying Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Pharmacology
Subjects:
hepatocellular carcinoma
tyrosine kinase inhibitor
programmed death-1 inhibitor
biomarkers
bile acid
treatment response
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1364924/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2024.1364924/full

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