Polypyrimidine tract binding protein knockdown reverses depression-like behaviors and cognition impairment in mice with lesioned cholinergic neurons

Polypyrimidine tract binding protein knockdown reverses depression-like behaviors and cognition impairment in mice with lesioned cholinergic neurons

Background and objectivesDepression is a common comorbidity of dementia and may be a risk factor for dementia. Accumulating evidence has suggested that the cholinergic system plays a central role in dementia and depression, and the loss of cholinergic neurons is associated with memory decline in agi...

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Bibliographic Details
Main Authors: Yiying Zhou, Ke Zhang, Fangmin Wang, Jiali Chen, Shanshan Chen, Manqing Wu, Miaojun Lai, Yisheng Zhang, Wenhua Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
cognition function
depression
polypyrimidine tract binding protein
acetylcholine
astrocyte
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1174341/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2023.1174341/full

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