A schizophrenia subgroup with elevated inflammation displays reduced microglia, increased peripheral immune cell and altered neurogenesis marker gene expression in the subependymal zone

A schizophrenia subgroup with elevated inflammation displays reduced microglia, increased peripheral immune cell and altered neurogenesis marker gene expression in the subependymal zone

Abstract Inflammation regulates neurogenesis, and the brains of patients with schizophrenia and bipolar disorder have reduced expression of neurogenesis markers in the subependymal zone (SEZ), the birthplace of inhibitory interneurons. Inflammation is associated with cortical interneuron deficits, b...

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Bibliographic Details
Main Authors: Hayley F. North, Christin Weissleder, Janice M. Fullerton, Rachel Sager, Maree J. Webster, Cynthia Shannon Weickert
Format: Article
Language:English
Published: Nature Publishing Group 2021-12-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-021-01742-8

Internet

https://doi.org/10.1038/s41398-021-01742-8

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