Cell type-specific function of TRAF2 and TRAF3 in regulating type I IFN induction

Cell type-specific function of TRAF2 and TRAF3 in regulating type I IFN induction

Abstract Background TRAF3 is known as a central mediator of type I interferon (IFN) induction by various pattern recognition receptors, but the in vivo function of TRAF3 in host defense against viral infection is poorly defined due to the lack of a viable mouse model. Results Here we show that mice...

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Bibliographic Details
Main Authors: Xiaoping Xie, Jin Jin, Lele Zhu, Zuliang Jie, Yanchuan Li, Baoyu Zhao, Xuhong Cheng, Pingwei Li, Shao-Cong Sun
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Cell & Bioscience
Subjects:
TRAF2
TRAF3
Type I interferon
Antiviral immunity
Online Access:http://link.springer.com/article/10.1186/s13578-018-0268-5

Internet

http://link.springer.com/article/10.1186/s13578-018-0268-5

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