Immunotherapy targeting isoDGR‐protein damage extends lifespan in a mouse model of protein deamidation

Immunotherapy targeting isoDGR‐protein damage extends lifespan in a mouse model of protein deamidation

Abstract Aging results from the accumulation of molecular damage that impairs normal biochemical processes. We previously reported that age‐linked damage to amino acid sequence NGR (Asn‐Gly‐Arg) results in “gain‐of‐function” conformational switching to isoDGR (isoAsp‐Gly‐Arg). This integrin‐binding...

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Bibliographic Details
Main Authors: Pazhanichamy Kalailingam, Khalilatul‐Hanisah Mohd‐Kahliab, SoFong Cam Ngan, Ranjith Iyappan, Evelin Melekh, Tian Lu, Gan Wei Zien, Bhargy Sharma, Tiannan Guo, Adam J MacNeil, Rebecca EK MacPherson, Evangelia Litsa Tsiani, Deborah D O'Leary, Kah Leong Lim, I Hsin Su, Yong‐Gui Gao, A Mark Richards, Raj N Kalaria, Christopher P Chen, Neil E McCarthy, Siu Kwan Sze
Format: Article
Language:English
Published: Springer Nature 2023-12-01
Series:EMBO Molecular Medicine
Subjects:
immunotherapy
inflammation
isoDGR
lifespan
Pcmt1
Online Access:https://doi.org/10.15252/emmm.202318526

Internet

https://doi.org/10.15252/emmm.202318526

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