Analysis of genomic and immune intratumor heterogeneity in linitis plastica via multiregional exome and T‐cell receptor sequencing

Analysis of genomic and immune intratumor heterogeneity in linitis plastica via multiregional exome and T‐cell receptor sequencing

The molecular landscape and the intratumor heterogeneity (ITH) architecture of gastric linitis plastica (LP) are poorly understood. We performed whole‐exome sequencing (WES) and T‐cell receptor (TCR) sequencing on 40 tumor regions from four LP patients. The landscape and ITH at the genomic and immun...

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Bibliographic Details
Main Authors: Jin Huang, Guofeng Zhao, Qiu Peng, Xin Yi, Liyan Ji, Jing Li, Pansong Li, Yanfang Guan, Jie Ge, Ling Chen, Runzhe Chen, Xin Hu, Won‐Chul Lee, Alexandre Reuben, P. Andrew Futreal, Xuefeng Xia, Jian Ma, Jianjun Zhang, Zihua Chen
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:Molecular Oncology
Subjects:
gastric linitis plastica
intratumor heterogeneity
multiregional whole‐exome sequencing
T‐cell receptor repertoires
Online Access:https://doi.org/10.1002/1878-0261.13381

Internet

https://doi.org/10.1002/1878-0261.13381

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