Hippocampal 7α-Hydroxylated Neurosteroids Are Raised by Training and Bolster Remote Spatial Memory with Increase of the Spine Densities

Summary: Neuroactive steroids, termed neurosteroids, are synthesized locally in the brain and influence biological functions including cognition and behavior. These neurosteroids are synthesized from cholesterol by a series of cytochrome P450 enzymes, among which a member of P450 hydroxylase, cytoch...

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Bibliographic Details
Main Authors: Kanako Maehata, Kimiko Shimizu, Tomoko Ikeno, Qiuyi Wang, Ayaka Sakurai, Zefeng Wei, Yue Pan, Toshifumi Takao, Yoshitaka Fukada
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220307513