PFKFB3 overexpression in monocytes of patients with colon but not rectal cancer programs pro-tumor macrophages and is indicative for higher risk of tumor relapse

PFKFB3 overexpression in monocytes of patients with colon but not rectal cancer programs pro-tumor macrophages and is indicative for higher risk of tumor relapse

IntroductionCirculating monocytes are main source for tumor-associated macrophages (TAMs) that control tumor growth, angiogenesis, metastasis and therapy resistance. We raised the questions how monocyte programming is affected by growing tumors localized in colon and rectal sections, and how treatme...

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Bibliographic Details
Main Authors: Irina Larionova, Marina Patysheva, Pavel Iamshchikov, Elena Kazakova, Anna Kazakova, Militsa Rakina, Evgeniya Grigoryeva, Anna Tarasova, Sergei Afanasiev, Natalia Bezgodova, Artem Kiselev, Alexey Dobrodeev, Dmitriy Kostromitskiy, Nadezhda Cherdyntseva, Julia Kzhyshkowska
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
monocyte
PFKFB3
colorectal cancer
tumor-associated macrophage
transcriptome
GeoMx DSP
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1080501/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1080501/full

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