Intranasal 17β-Estradiol Modulates Spatial Learning and Memory in a Rat Model of Surgical Menopause

Intranasal 17β-Estradiol Modulates Spatial Learning and Memory in a Rat Model of Surgical Menopause

Exogenously administered 17β-estradiol (E2) can improve spatial learning and memory, although E2 also exerts undesired effects on peripheral organs. Clinically, E2 has been solubilized in cyclodextrin for intranasal administration, which enhances brain-specific delivery. Prior work shows that the cy...

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Bibliographic Details
Main Authors: Alesia V. Prakapenka, Veronica L. Peña, Isabel Strouse, Steven Northup-Smith, Ally Schrier, Kinza Ahmed, Heather A. Bimonte-Nelson, Rachael W. Sirianni
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Pharmaceutics
Subjects:
estrogen
intranasal
cyclodextrin
delivery
menopause
learning
Online Access:https://www.mdpi.com/1999-4923/12/12/1225

Internet

https://www.mdpi.com/1999-4923/12/12/1225

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