NMR Spectroscopy for Protein Higher Order Structure Similarity Assessment in Formulated Drug Products

NMR Spectroscopy for Protein Higher Order Structure Similarity Assessment in Formulated Drug Products

Peptide and protein drug molecules fold into higher order structures (HOS) in formulation and these folded structures are often critical for drug efficacy and safety. Generic or biosimilar drug products (DPs) need to show similar HOS to the reference product. The solution NMR spectroscopy is a non-i...

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Bibliographic Details
Main Authors: Deyun Wang, You Zhuo, Mike Karfunkle, Sharadrao M. Patil, Cameron J. Smith, David A. Keire, Kang Chen
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Molecules
Subjects:
similarity metrics
Mahalanobis distance
chemical shift difference
peak profile
relative peak height
Online Access:https://www.mdpi.com/1420-3049/26/14/4251

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https://www.mdpi.com/1420-3049/26/14/4251

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