Induction of Endoplasmic Reticulum Stress-Mediated Apoptosis by Aminosteroid RM-581 Efficiently Blocks the Growth of PC-3 Cancer Cells and Tumors Resistant or Not to Docetaxel

Induction of Endoplasmic Reticulum Stress-Mediated Apoptosis by Aminosteroid RM-581 Efficiently Blocks the Growth of PC-3 Cancer Cells and Tumors Resistant or Not to Docetaxel

Aminosteroid derivative RM-581 was previously identified as an endoplasmic-reticulum (ER) stress inducer with potent in vitro and in vivo anticancer activities. We report its evaluation in androgen-independent prostate cancer (PC-3) cells. RM-581 efficiently blocks PC-3 cell proliferation with stron...

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Bibliographic Details
Main Authors: René Maltais, Jenny Roy, Martin Perreault, Sachiko Sato, Julie-Christine Lévesque, Donald Poirier
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
prostate cancer
aminosteroid
endoplasmic reticulum stress
cholesterol
fatty acid
Online Access:https://www.mdpi.com/1422-0067/22/20/11181

Internet

https://www.mdpi.com/1422-0067/22/20/11181

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