Regulation of brain endothelial cell physiology by the TAM receptor tyrosine kinase Mer

Abstract The receptor tyrosine kinase Mer (gene name Mertk) acts in vascular endothelial cells (ECs) to tighten the blood-brain barrier (BBB) subsequent to viral infection, but how this is achieved is poorly understood. We find that Mer controls the expression and activity of a large cohort of BBB r...

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Bibliographic Details
Main Authors: Kaisa E. Happonen, Patrick G. Burrola, Greg Lemke
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-05287-y