HRD1 inhibits fatty acid oxidation and tumorigenesis by ubiquitinating CPT2 in triple‐negative breast cancer

HRD1 inhibits fatty acid oxidation and tumorigenesis by ubiquitinating CPT2 in triple‐negative breast cancer

Dependence on glutamine and acceleration of fatty acid oxidation (FAO) are both metabolic characteristics of triple‐negative breast cancer (TNBC). With the rapid growth of tumors, accelerated glutamine catabolism depletes local glutamine, resulting in glutamine deficiency. Studies have shown that th...

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Bibliographic Details
Main Authors: Xin Guo, Aman Wang, Wen Wang, Ya Wang, Huan Chen, Xiaolong Liu, Tian Xia, Aijia Zhang, Di Chen, Huan Qi, Ting Ling, Hai‐long Piao, Hong‐jiang Wang
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Molecular Oncology
Subjects:
CPT2
FAO
HRD1
TNBC
ubiquitination
Online Access:https://doi.org/10.1002/1878-0261.12856

Internet

https://doi.org/10.1002/1878-0261.12856

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