Tau Pathology Profile Across a Parietal-Hippocampal Brain Network Is Associated With Spatial Reorientation Learning and Memory Performance in the 3xTg-AD Mouse

Tau Pathology Profile Across a Parietal-Hippocampal Brain Network Is Associated With Spatial Reorientation Learning and Memory Performance in the 3xTg-AD Mouse

In early Alzheimer's disease (AD) spatial navigation is one of the first impairments to emerge; however, the precise cause of this impairment is unclear. Previously, we showed that, in a mouse model of tau and amyloid beta (Aβ) aggregation, getting lost represents, at least in part, a failure t...

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Bibliographic Details
Main Authors: Alina C. Stimmell, Zishen Xu, Shawn C. Moseley, Sarah D. Cushing, Diana M. Fernandez, Jessica V. Dang, Luis F. Santos-Molina, Rosina A. Anzalone, Carolina L. Garcia-Barbon, Stephany Rodriguez, Jessica R. Dixon, Wei Wu, Aaron A. Wilber
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Aging
Subjects:
spatial reorientation
hippocampal
parietal
subiculum
retrosplenical cortex
spatial learning and memory
Online Access:https://www.frontiersin.org/articles/10.3389/fragi.2021.655015/full

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https://www.frontiersin.org/articles/10.3389/fragi.2021.655015/full

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