Current Challenges in Providing Good Leukapheresis Products for Manufacturing of CAR-T Cells for Patients with Relapsed/Refractory NHL or ALL

Current Challenges in Providing Good Leukapheresis Products for Manufacturing of CAR-T Cells for Patients with Relapsed/Refractory NHL or ALL

Background: T lymphocyte collection through leukapheresis is an essential step for chimeric antigen receptor T (CAR-T) cell therapy. Timing of apheresis is challenging in heavily pretreated patients who suffer from rapid progressive disease and receive T cell impairing medication. Methods: A total o...

Full description

Bibliographic Details
Main Authors: Felix Korell, Sascha Laier, Sandra Sauer, Kaya Veelken, Hannah Hennemann, Maria-Luisa Schubert, Tim Sauer, Petra Pavel, Carsten Mueller-Tidow, Peter Dreger, Michael Schmitt, Anita Schmitt
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
CAR T cell
apheresis
lymphocyte collection
CD3 positive lymphocytes
Online Access:https://www.mdpi.com/2073-4409/9/5/1225

Internet

https://www.mdpi.com/2073-4409/9/5/1225

Similar Items