Silencing CDCA8 Suppresses Hepatocellular Carcinoma Growth and Stemness via Restoration of ATF3 Tumor Suppressor and Inactivation of AKT/β–Catenin Signaling

Silencing CDCA8 Suppresses Hepatocellular Carcinoma Growth and Stemness via Restoration of ATF3 Tumor Suppressor and Inactivation of AKT/β–Catenin Signaling

Big data analysis has revealed the upregulation of cell division cycle associated 8 (CDCA8) in human hepatocellular carcinoma (HCC) and its poorer survival outcome. However, the functions of CDCA8 during HCC development remain unknown. Here, we demonstrate in vitro that CDCA8 silencing inhibits HCC...

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Bibliographic Details
Main Authors: Taewon Jeon, Min Ji Ko, Yu-Ri Seo, Soo-Jung Jung, Daekwan Seo, So-Young Park, Keon Uk Park, Kwang Seok Kim, Mikyung Kim, Ji Hae Seo, In-Chul Park, Min-Ji Kim, Jae-Hoon Bae, Dae-Kyu Song, Chi Heum Cho, Jae-Ho Lee, Yun-Han Lee
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
CDCA8
mitosis
HCC
tumor growth
ATF3
GADD34
Online Access:https://www.mdpi.com/2072-6694/13/5/1055

Internet

https://www.mdpi.com/2072-6694/13/5/1055

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