Oxidative Stress and Mitochondrial Abnormalities Contribute to Decreased Endothelial Nitric Oxide Synthase Expression and Renal Disease Progression in Early Experimental Polycystic Kidney Disease

Oxidative Stress and Mitochondrial Abnormalities Contribute to Decreased Endothelial Nitric Oxide Synthase Expression and Renal Disease Progression in Early Experimental Polycystic Kidney Disease

Vascular abnormalities are the most important non-cystic complications in Polycystic Kidney Disease (PKD) and contribute to renal disease progression. Endothelial dysfunction and oxidative stress are evident in patients with ADPKD, preserved renal function, and controlled hypertension. The underlyin...

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Bibliographic Details
Main Authors: Alp S. Kahveci, Tania T. Barnatan, Ali Kahveci, Alexis E. Adrian, Jennifer Arroyo, Alfonso Eirin, Peter C. Harris, Amir Lerman, Lilach O. Lerman, Vicente E. Torres, Maria V. Irazabal
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
polycystic kidney disease
oxidative stress
nox4
mitochondria
endothelial dysfunction
Online Access:https://www.mdpi.com/1422-0067/21/6/1994

Internet

https://www.mdpi.com/1422-0067/21/6/1994

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