Doubly Phosphorylated Peptide Vaccines to Protect Transgenic P301S Mice against Alzheimer’s Disease Like Tau Aggregation

Doubly Phosphorylated Peptide Vaccines to Protect Transgenic P301S Mice against Alzheimer’s Disease Like Tau Aggregation

Intracellular neurofibrillary tangles and extracellular senile plaques are potential targets for active and passive immunotherapies. In this study we used the transgenic mouse model P301S for active immunizations with peptide vaccines composed of a double phosphorylated tau neoepitope (pSer202/pThr2...

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Bibliographic Details
Main Authors: Monique Richter, Agneta Mewes, Manuela Fritsch, Ute Krügel, Ralf Hoffmann, David Singer
Format: Article
Language:English
Published: MDPI AG 2014-07-01
Series:Vaccines
Subjects:
Alzheimer’s disease
immunization
peptide vaccine
phospho-tau
transgenic mouse model
P301S mice
Online Access:http://www.mdpi.com/2076-393X/2/3/601

Internet

http://www.mdpi.com/2076-393X/2/3/601

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