Pharmacokinetic/Pharmacodynamic Evaluation of Aztreonam/Amoxicillin/Clavulanate Combination against New Delhi Metallo-β-Lactamase and Serine-β-Lactamase Co-Producing <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i>

Pharmacokinetic/Pharmacodynamic Evaluation of Aztreonam/Amoxicillin/Clavulanate Combination against New Delhi Metallo-β-Lactamase and Serine-β-Lactamase Co-Producing <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i>

This study aimed to examine specific niches and usage for the aztreonam/amoxicillin/clavulanate combination and to use population pharmacokinetic simulations of clinical dosing regimens to predict the impact of this combination on restricting mutant selection. The in vitro susceptibility of 19 New-D...

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Bibliographic Details
Main Authors: Jiayuan Zhang, Mengyuan Wu, Shuo Diao, Shixing Zhu, Chu Song, Jiali Yue, Frederico S. Martins, Peijuan Zhu, Zhihua Lv, Yuanqi Zhu, Mingming Yu, Sherwin K. B. Sy
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pharmaceutics
Subjects:
<i>Klebsiella pneumoniae</i>
<i>Escherichia coli</i>
NDM
MPC
pharmacodynamics
Online Access:https://www.mdpi.com/1999-4923/15/1/251

Internet

https://www.mdpi.com/1999-4923/15/1/251

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