Deficiency in AK9 causes asthenozoospermia and male infertility by destabilising sperm nucleotide homeostasisResearch in context

Summary: Background: Asthenozoospermia is the primary cause of male infertility; however, its genetic aetiology remains poorly understood. Adenylate kinase 9 (AK9) is highly expressed in the testes of humans and mice and encodes a type of adenosine kinase that is functionally involved in cellular n...

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Bibliographic Details
Main Authors: Yanwei Sha, Wensheng Liu, Shu Li, Ludmila V. Osadchuk, Yongjie Chen, Hua Nie, Shuai Gao, Linna Xie, Weibing Qin, Huiliang Zhou, Lin Li
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:EBioMedicine
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S235239642300364X