JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension

Abstract Pulmonary arterial hypertension (PAH) is a chronic disorder characterized by hyperproliferation of pulmonary arterial smooth muscle cells (PASMCs). JMJD1C, a member of the Jumonji domain containing C (JMJC) histone demethylase family, contributes to cardiovascular dysfunction. However, the...

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Bibliographic Details
Main Authors: Chen Zhang, Yue Sun, Yingying Guo, Jingjing Xu, Haiyan Zhao
Format: Article
Language:English
Published: Nature Publishing Group 2023-03-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01390-5