Potential in vitro anti-neuroinflammatory sterols from mango fruits (Mangifera indica L.)
Mango is one of the most popular fruit in tropical and subtropical regions of the world. In this study, previously undescribed two sterols (1–2) and one terpenoid (10), as well as ten known phytochemicals (3–9, 11–13), were isolated and identified from mango fruits. In vitro anti-neuroinflammatory a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464621002255 |
| _version_ | 1818922415078506496 |
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| author | Liangmiao Luo Yi Wang Yihai Wang Jingwen Xu Xiangjiu He |
| author_facet | Liangmiao Luo Yi Wang Yihai Wang Jingwen Xu Xiangjiu He |
| author_sort | Liangmiao Luo |
| collection | DOAJ |
| description | Mango is one of the most popular fruit in tropical and subtropical regions of the world. In this study, previously undescribed two sterols (1–2) and one terpenoid (10), as well as ten known phytochemicals (3–9, 11–13), were isolated and identified from mango fruits. In vitro anti-neuroinflammatory activity of the purified compounds was evaluated and most of them exhibited pronounced bioactivity. Among them, compounds 2 and 5 exhibited the most significant anti-neuroinflammatory effects, which were comparable to that of indomethacin (positive control) and suggested that the sterols in the fruits of mango played important roles for the anti-neuroinflammatory activity. Further, Western blotting, quantitative PCR and immunofluorescence staining assays were performed to confirm that compounds 2 and 5 exerted the anti-neuroinflammatory through the NF-κB pathway. The study provided a phytochemical evidence for further development and utilization of the fruits of mango in health products. |
| first_indexed | 2024-12-20T01:53:10Z |
| format | Article |
| id | doaj.art-0e97336200b5426bb1f93f0269c19169 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-20T01:53:10Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-0e97336200b5426bb1f93f0269c191692022-12-21T19:57:35ZengElsevierJournal of Functional Foods1756-46462021-09-0184104576Potential in vitro anti-neuroinflammatory sterols from mango fruits (Mangifera indica L.)Liangmiao Luo0Yi Wang1Yihai Wang2Jingwen Xu3Xiangjiu He4School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Engineering Research Center for Lead Compounds & Drug Discovery, Guangzhou 510006, China; Corresponding authors at: School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Engineering Research Center for Lead Compounds & Drug Discovery, Guangzhou 510006, ChinaSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Engineering Research Center for Lead Compounds & Drug Discovery, Guangzhou 510006, China; Corresponding authors at: School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.Mango is one of the most popular fruit in tropical and subtropical regions of the world. In this study, previously undescribed two sterols (1–2) and one terpenoid (10), as well as ten known phytochemicals (3–9, 11–13), were isolated and identified from mango fruits. In vitro anti-neuroinflammatory activity of the purified compounds was evaluated and most of them exhibited pronounced bioactivity. Among them, compounds 2 and 5 exhibited the most significant anti-neuroinflammatory effects, which were comparable to that of indomethacin (positive control) and suggested that the sterols in the fruits of mango played important roles for the anti-neuroinflammatory activity. Further, Western blotting, quantitative PCR and immunofluorescence staining assays were performed to confirm that compounds 2 and 5 exerted the anti-neuroinflammatory through the NF-κB pathway. The study provided a phytochemical evidence for further development and utilization of the fruits of mango in health products.http://www.sciencedirect.com/science/article/pii/S1756464621002255MangoMangifera indica L.SterolsAnti-neuroinflammatory activityiNOSCOX-2 |
| spellingShingle | Liangmiao Luo Yi Wang Yihai Wang Jingwen Xu Xiangjiu He Potential in vitro anti-neuroinflammatory sterols from mango fruits (Mangifera indica L.) Journal of Functional Foods Mango Mangifera indica L. Sterols Anti-neuroinflammatory activity iNOS COX-2 |
| title | Potential in vitro anti-neuroinflammatory sterols from mango fruits (Mangifera indica L.) |
| title_full | Potential in vitro anti-neuroinflammatory sterols from mango fruits (Mangifera indica L.) |
| title_fullStr | Potential in vitro anti-neuroinflammatory sterols from mango fruits (Mangifera indica L.) |
| title_full_unstemmed | Potential in vitro anti-neuroinflammatory sterols from mango fruits (Mangifera indica L.) |
| title_short | Potential in vitro anti-neuroinflammatory sterols from mango fruits (Mangifera indica L.) |
| title_sort | potential in vitro anti neuroinflammatory sterols from mango fruits mangifera indica l |
| topic | Mango Mangifera indica L. Sterols Anti-neuroinflammatory activity iNOS COX-2 |
| url | http://www.sciencedirect.com/science/article/pii/S1756464621002255 |
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