Synthesis, Biological and In Silico Evaluation of Pure Nucleobase-Containing Spiro (Indane-Isoxazolidine) Derivatives as Potential Inhibitors of MDM2–p53 Interaction

Synthesis, Biological and In Silico Evaluation of Pure Nucleobase-Containing Spiro (Indane-Isoxazolidine) Derivatives as Potential Inhibitors of MDM2–p53 Interaction

Nucleobase-containing isoxazolidines spiro-bonded to an indane core have been synthesized in very good yields by regio- and diastereoselective 1,3-dipolar cycloaddition starting from indanyl nitrones and <i>N</i>-vinylnucleobases by using environmentally benign microwave technology. The...

Full description

Bibliographic Details
Main Authors: Loredana Maiuolo, Vincenzo Algieri, Beatrice Russo, Matteo Antonio Tallarida, Monica Nardi, Maria Luisa Di Gioia, Zahra Merchant, Pedro Merino, Ignacio Delso, Antonio De Nino
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Molecules
Subjects:
spirooxindoles
isoxazolidines
MDM2–p53 inhibition
indane derivatives
Online Access:https://www.mdpi.com/1420-3049/24/16/2909

Internet

https://www.mdpi.com/1420-3049/24/16/2909

Similar Items