Metabolic and Pharmacokinetic Differentiation of STX209 and Racemic Baclofen in Humans

STX209 is an exploratory drug comprising the single, active R-enantiomer of baclofen which is in later stage clinical trials for the treatment of fragile x syndrome (FXS) and autism spectrum disorders (ASD). New clinical data in this article on the metabolism and pharmacokinetics of the R- and S-ena...

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Bibliographic Details
Main Authors: Raymundo Sanchez-Ponce, Li-Quan Wang, Wei Lu, Jana von Hehn, Maryann Cherubini, Roger Rush
Format: Article
Language:English
Published: MDPI AG 2012-09-01
Series:Metabolites
Subjects:
Online Access:http://www.mdpi.com/2218-1989/2/3/596