Protein interaction, cytotoxic, transcriptomic and proteomic responses to structurally distinct EPAC1 activators in HUVECs

Protein interaction, cytotoxic, transcriptomic and proteomic responses to structurally distinct EPAC1 activators in HUVECs

Abstract The N-acylsulfonamide derivative, I942, represents the first non-cyclic nucleotide partial agonist of EPAC1. This was soon followed by the identification of the I942 analogues, PW0381, PW0521 and PWO577 and a series of benzofuran oxoacetic acid EPAC1 activators, SY006, SY007 and SY009. Prot...

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Bibliographic Details
Main Authors: Jolanta Wiejak, Urszula Luchowska-Stańska, Pingyuan Wang, Jia Zhou, Pasquale Maffia, David Morgan, Graeme Barker, Stephen J. Yarwood
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-20607-8

Internet

https://doi.org/10.1038/s41598-022-20607-8

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