Structural Determinant of β-Amyloid Formation: From Transmembrane Protein Dimerization to β-Amyloid Aggregates

Structural Determinant of β-Amyloid Formation: From Transmembrane Protein Dimerization to β-Amyloid Aggregates

Most neurodegenerative diseases have the characteristics of protein folding disorders, i.e., they cause lesions to appear in vulnerable regions of the nervous system, corresponding to protein aggregates that progressively spread through the neuronal network as the symptoms progress. Alzheimer’s dise...

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Bibliographic Details
Main Authors: Nicolas Papadopoulos, Nuria Suelves, Florian Perrin, Devkee M. Vadukul, Céline Vrancx, Stefan N. Constantinescu, Pascal Kienlen-Campard
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Biomedicines
Subjects:
Alzheimer’s disease
Amyloid Precursor Protein
amyloid beta
<i>APP</i>-C99
dimerization
orientations
Online Access:https://www.mdpi.com/2227-9059/10/11/2753

Internet

https://www.mdpi.com/2227-9059/10/11/2753

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