Inhibition of the calcium-sensing receptor by extracellular phosphate ions and by intracellular phosphorylation
As both a sensor of extracellular calcium (Ca2+o) concentration and a key controller of Ca2+o homeostasis, one of the most interesting properties of the calcium-sensing receptor (CaR) is its sensitivity to, and modulation by, ions and small ligands other than Ca2+. There is emerging evidence that ex...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1154374/full |
| _version_ | 1797855174184665088 |
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| author | Patricia P. Centeno Lenah S. Binmahfouz Lenah S. Binmahfouz Khaleda Alghamdi Khaleda Alghamdi Donald T. Ward |
| author_facet | Patricia P. Centeno Lenah S. Binmahfouz Lenah S. Binmahfouz Khaleda Alghamdi Khaleda Alghamdi Donald T. Ward |
| author_sort | Patricia P. Centeno |
| collection | DOAJ |
| description | As both a sensor of extracellular calcium (Ca2+o) concentration and a key controller of Ca2+o homeostasis, one of the most interesting properties of the calcium-sensing receptor (CaR) is its sensitivity to, and modulation by, ions and small ligands other than Ca2+. There is emerging evidence that extracellular phosphate can act as a partial, non-competitive CaR antagonist to modulate parathyroid hormone (PTH) secretion, thus permitting the CaR to integrate mineral homeostasis more broadly. Interestingly, phosphorylation of certain intracellular CaR residues can also inhibit CaR responsiveness. Thus, negatively charged phosphate can decrease CaR activity both extracellularly (via association with arginine) and intracellularly (via covalent phosphorylation). |
| first_indexed | 2024-04-09T20:19:28Z |
| format | Article |
| id | doaj.art-0eaee1cbbf1b4c45bdc45d9c8ad21c45 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-09T20:19:28Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-0eaee1cbbf1b4c45bdc45d9c8ad21c452023-03-31T06:29:39ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-03-011410.3389/fphys.2023.11543741154374Inhibition of the calcium-sensing receptor by extracellular phosphate ions and by intracellular phosphorylationPatricia P. Centeno0Lenah S. Binmahfouz1Lenah S. Binmahfouz2Khaleda Alghamdi3Khaleda Alghamdi4Donald T. Ward5Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United KingdomFaculty of Biology, Medicine and Health, The University of Manchester, Manchester, United KingdomDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi ArabiaFaculty of Biology, Medicine and Health, The University of Manchester, Manchester, United KingdomDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi ArabiaFaculty of Biology, Medicine and Health, The University of Manchester, Manchester, United KingdomAs both a sensor of extracellular calcium (Ca2+o) concentration and a key controller of Ca2+o homeostasis, one of the most interesting properties of the calcium-sensing receptor (CaR) is its sensitivity to, and modulation by, ions and small ligands other than Ca2+. There is emerging evidence that extracellular phosphate can act as a partial, non-competitive CaR antagonist to modulate parathyroid hormone (PTH) secretion, thus permitting the CaR to integrate mineral homeostasis more broadly. Interestingly, phosphorylation of certain intracellular CaR residues can also inhibit CaR responsiveness. Thus, negatively charged phosphate can decrease CaR activity both extracellularly (via association with arginine) and intracellularly (via covalent phosphorylation).https://www.frontiersin.org/articles/10.3389/fphys.2023.1154374/fullcalcium-sensing receptorparathyroid hormonephosphate-sensingsecondary hyperparathyroidismreceptor phosphorylation |
| spellingShingle | Patricia P. Centeno Lenah S. Binmahfouz Lenah S. Binmahfouz Khaleda Alghamdi Khaleda Alghamdi Donald T. Ward Inhibition of the calcium-sensing receptor by extracellular phosphate ions and by intracellular phosphorylation Frontiers in Physiology calcium-sensing receptor parathyroid hormone phosphate-sensing secondary hyperparathyroidism receptor phosphorylation |
| title | Inhibition of the calcium-sensing receptor by extracellular phosphate ions and by intracellular phosphorylation |
| title_full | Inhibition of the calcium-sensing receptor by extracellular phosphate ions and by intracellular phosphorylation |
| title_fullStr | Inhibition of the calcium-sensing receptor by extracellular phosphate ions and by intracellular phosphorylation |
| title_full_unstemmed | Inhibition of the calcium-sensing receptor by extracellular phosphate ions and by intracellular phosphorylation |
| title_short | Inhibition of the calcium-sensing receptor by extracellular phosphate ions and by intracellular phosphorylation |
| title_sort | inhibition of the calcium sensing receptor by extracellular phosphate ions and by intracellular phosphorylation |
| topic | calcium-sensing receptor parathyroid hormone phosphate-sensing secondary hyperparathyroidism receptor phosphorylation |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1154374/full |
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