Ascl1 phospho-site mutations enhance neuronal conversion of adult cortical astrocytes in vivo

Ascl1 phospho-site mutations enhance neuronal conversion of adult cortical astrocytes in vivo

Direct neuronal reprogramming, the process whereby a terminally differentiated cell is converted into an induced neuron without traversing a pluripotent state, has tremendous therapeutic potential for a host of neurodegenerative diseases. While there is strong evidence for astrocyte-to-neuron conver...

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Bibliographic Details
Main Authors: Hussein Ghazale, EunJee Park, Lakshmy Vasan, James Mester, Fermisk Saleh, Andrea Trevisiol, Dawn Zinyk, Vorapin Chinchalongporn, Mingzhe Liu, Taylor Fleming, Oleksandr Prokopchuk, Natalia Klenin, Deborah Kurrasch, Maryam Faiz, Bojana Stefanovic, JoAnne McLaurin, Carol Schuurmans
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Neuroscience
Subjects:
proneural bHLH transcription factors
phospho-site mutations
neuronal reprogramming
cerebral cortex
astrocytes
induced neuron
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.917071/full

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https://www.frontiersin.org/articles/10.3389/fnins.2022.917071/full

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