The CIC-ERF co-deletion underlies fusion-independent activation of ETS family member, ETV1, to drive prostate cancer progression

The CIC-ERF co-deletion underlies fusion-independent activation of ETS family member, ETV1, to drive prostate cancer progression

Human prostate cancer can result from chromosomal rearrangements that lead to aberrant ETS gene expression. The mechanisms that lead to fusion-independent ETS factor upregulation and prostate oncogenesis remain relatively unknown. Here, we show that two neighboring transcription factors, Capicua (CI...

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Bibliographic Details
Main Authors: Nehal Gupta, Hanbing Song, Wei Wu, Rovingaile K Ponce, Yone K Lin, Ji Won Kim, Eric J Small, Felix Y Feng, Franklin W Huang, Ross A Okimoto
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-11-01
Series:eLife
Subjects:
prostate cancer
Capicua
ERF
ETS transcription factors
Online Access:https://elifesciences.org/articles/77072

Internet

https://elifesciences.org/articles/77072

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