Peripheral Leukocytosis Is Inversely Correlated with Intratumoral CD8+ T-Cell Infiltration and Associated with Worse Outcome after Chemoradiotherapy in Anal Cancer

Peripheral Leukocytosis Is Inversely Correlated with Intratumoral CD8+ T-Cell Infiltration and Associated with Worse Outcome after Chemoradiotherapy in Anal Cancer

Peripheral blood leukocytosis has been implicated in promoting tumor progression leading to worse survival, but the mechanisms behind this phenomenon remain unexplored. Here, we examined the prognostic role of pretreatment white blood cell (WBC) count and clinicopathologic parameters in the context...

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Bibliographic Details
Main Authors: Daniel Martin, Franz Rödel, Ria Winkelmann, Panagiotis Balermpas, Claus Rödel, Emmanouil Fokas
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Immunology
Subjects:
anal cancer
leukocytosis
immune microenvironment
tumor-infiltrating-lymphocytes
neutrophils
CD8
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01225/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01225/full

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