Erianin suppresses constitutive activation of MAPK signaling pathway by inhibition of CRAF and MEK1/2

Erianin suppresses constitutive activation of MAPK signaling pathway by inhibition of CRAF and MEK1/2

Abstract Constitutive activation of RAS-RAF-MEK-ERK signaling pathway (MAPK pathway) frequently occurs in many cancers harboring RAS or RAF oncogenic mutations. Because of the paradoxical activation induced by a single use of BRAF or MEK inhibitors, dual-target RAF and MEK treatment is thought to be...

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Bibliographic Details
Main Authors: Penglei Wang, Xuechao Jia, Bingbing Lu, Han Huang, Jialin Liu, Xuejiao Liu, Qiong Wu, Yamei Hu, Pan Li, Huifang Wei, Tingting Liu, Dengyun Zhao, Lingwei Zhang, Xueli Tian, Yanan Jiang, Yan Qiao, Wenna Nie, Xinli Ma, Ruihua Bai, Cong Peng, Zigang Dong, Kangdong Liu
Format: Article
Language:English
Published: Nature Publishing Group 2023-03-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-023-01329-3

Internet

https://doi.org/10.1038/s41392-023-01329-3

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