Circulating cell-free methylated DNA reveals tissue-specific, cellular damage from radiation treatment

Circulating cell-free methylated DNA reveals tissue-specific, cellular damage from radiation treatment

Radiation therapy is an effective cancer treatment, although damage to healthy tissues is common. Here we analyzed cell-free, methylated DNA released from dying cells into the circulation to evaluate radiation-induced cellular damage in different tissues. To map the circulating DNA fragments to huma...

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Bibliographic Details
Main Authors: Megan E. McNamara, Netanel Loyfer, Amber J. Kiliti, Marcel O. Schmidt, Sapir Shabi-Porat, Sidharth S. Jain, Sarah Martinez Roth, A. Patrick McDeed IV, Nesreen Shahrour, Elizabeth Ballew, Yun-Tien Lin, Heng-Hong Li, Anne Deslattes Mays, Sonali Rudra, Anna T. Riegel, Keith Unger, Tommy Kaplan, Anton Wellstein
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-07-01
Series:JCI Insight
Subjects:
Genetics
Oncology
Online Access:https://doi.org/10.1172/jci.insight.156529

Internet

https://doi.org/10.1172/jci.insight.156529

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