Metabolic reprogramming during hyperammonemia targets mitochondrial function and postmitotic senescence

Metabolic reprogramming during hyperammonemia targets mitochondrial function and postmitotic senescence

Ammonia is a cytotoxic metabolite with pleiotropic molecular and metabolic effects, including senescence induction. During dysregulated ammonia metabolism, which occurs in chronic diseases, skeletal muscle becomes a major organ for nonhepatocyte ammonia uptake. Muscle ammonia disposal occurs in mito...

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Bibliographic Details
Main Authors: Avinash Kumar, Nicole Welch, Saurabh Mishra, Annette Bellar, Rafaella Nasciemento Silva, Ling Li, Shashi Shekhar Singh, Mary Sharkoff, Alexis Kerr, Aruna Kumar Chelluboyina, Jinendiran Sekar, Amy H. Attaway, Charles Hoppel, Belinda Willard, Gangarao Davuluri, Srinivasan Dasarathy
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-12-01
Series:JCI Insight
Subjects:
Cell biology
Hepatology
Online Access:https://doi.org/10.1172/jci.insight.154089

Internet

https://doi.org/10.1172/jci.insight.154089

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