Mesenchymal Stem Cell-Induced DDR2 Mediates Stromal-Breast Cancer Interactions and Metastasis Growth

Mesenchymal Stem Cell-Induced DDR2 Mediates Stromal-Breast Cancer Interactions and Metastasis Growth

Increased collagen deposition by breast cancer (BC)-associated mesenchymal stem/multipotent stromal cells (MSC) promotes metastasis, but the mechanisms are unknown. Here, we report that the collagen receptor discoidin domain receptor 2 (DDR2) is essential for stromal-BC communication. In human BC me...

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Bibliographic Details
Main Authors: Maria E. Gonzalez, Emily E. Martin, Talha Anwar, Caroline Arellano-Garcia, Natasha Medhora, Arjun Lama, Yu-Chih Chen, Kevin S. Tanager, Euisik Yoon, Kelley M. Kidwell, Chunxi Ge, Renny T. Franceschi, Celina G. Kleer
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Cell Reports
Subjects:
mesenchymal stem cell
tumor stroma
breast cancer
metastasis
DDR2
discoidin domain receptor
collagen
microenvironment
phosphorylated DDR2
EZH2
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716318010

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http://www.sciencedirect.com/science/article/pii/S2211124716318010

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