tsRNA-04002 alleviates intervertebral disk degeneration by targeting PRKCA to inhibit apoptosis of nucleus pulposus cells

tsRNA-04002 alleviates intervertebral disk degeneration by targeting PRKCA to inhibit apoptosis of nucleus pulposus cells

Abstract Background Intervertebral disk degeneration (IDD) is a degenerative disease that underlies various musculoskeletal and spinal disorders and is positively correlated with age. tRNA-derived small RNAs (tsRNA), as a new small noncoding RNAs, its function in IDD is unclear. Herein, our goal was...

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Bibliographic Details
Main Authors: Jie Pan, Zhonghan Liu, Bin Shen, Jin Xu, Gonghua Dai, Wen Xu, Jianjie Wang, Lijun Li, Liming Cheng
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Intervertebral disk degeneration
Apoptosis
Inflammatory cytokines
Nucleus pulposus cells
tsRNA-04002
PRKCA
Online Access:https://doi.org/10.1186/s13018-023-03878-3

Internet

https://doi.org/10.1186/s13018-023-03878-3

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