Global and tissue-specific aging effects on murine proteomes

Summary: Maintenance of protein homeostasis degrades with age, contributing to aging-related decline and disease. Previous studies have primarily surveyed transcriptional aging changes. To define the effects of age directly at the protein level, we perform discovery-based proteomics in 10 tissues fr...

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Bibliographic Details
Main Authors: Gregory R. Keele, Ji-Gang Zhang, John Szpyt, Ron Korstanje, Steven P. Gygi, Gary A. Churchill, Devin K. Schweppe
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472300726X