Dexmedetomidine ameliorates hyperalgesia of rat models with neuropathic pain via upregulation of PPAR-γ

Dexmedetomidine ameliorates hyperalgesia of rat models with neuropathic pain via upregulation of PPAR-γ

Objective To explore the analgesic effect and underlying mechanisms of dexmedetomidine(DEX) with spared nerve injury(SNI) rat model. Methods Forty-eight SD rats were randomly divided into control group, SNI group, DEX group and DEX+GW9662 group, with 12 rats in each. From first day to 14th days afte...

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Bibliographic Details
Main Author: ZHU Feng, ZHONG Yue, DENG Yijiang, LIU Wenzhi, BIAN Jiang
Format: Article
Language:zho
Published: Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. 2023-09-01
Series:Jichu yixue yu linchuang
Subjects:
dexmedetomidine|neuropathic pain|microglia|peroxisome proliferator-activated receptor-γ(ppar-γ)
Online Access:http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2023-43-9-1369.pdf

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http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2023-43-9-1369.pdf

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