Effect of Ivermectin and Atorvastatin on Nuclear Localization of Importin Alpha and Drug Target Expression Profiling in Host Cells from Nasopharyngeal Swabs of SARS-CoV-2- Positive Patients

Effect of Ivermectin and Atorvastatin on Nuclear Localization of Importin Alpha and Drug Target Expression Profiling in Host Cells from Nasopharyngeal Swabs of SARS-CoV-2- Positive Patients

Nuclear transport and vesicle trafficking are key cellular functions involved in the pathogenesis of RNA viruses. Among other pleiotropic effects on virus-infected host cells, ivermectin (IVM) inhibits nuclear transport mechanisms mediated by importins and atorvastatin (ATV) affects actin cytoskelet...

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Bibliographic Details
Main Authors: Valeria Inés Segatori, Juan Garona, Lorena Grisel Caligiuri, Juan Bizzotto, Rosario Lavignolle, Ayelén Toro, Pablo Sanchis, Eduardo Spitzer, Alejandro Krolewiecki, Geraldine Gueron, Daniel Fernando Alonso
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Viruses
Subjects:
SARS-CoV-2
COVID-19
drug repurposing
antihelmintic drug
lipophilic statin
host cell antiviral response
Online Access:https://www.mdpi.com/1999-4915/13/10/2084

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https://www.mdpi.com/1999-4915/13/10/2084

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