Supraphysiologic doses of 17β-estradiol aggravate depression-like behaviors in ovariectomized mice possibly via regulating microglial responses and brain glycerophospholipid metabolism

Supraphysiologic doses of 17β-estradiol aggravate depression-like behaviors in ovariectomized mice possibly via regulating microglial responses and brain glycerophospholipid metabolism

Abstract Background 17β-Estradiol (E2) is generally considered neuroprotective in humans. However, the current clinical use of estrogen replacement therapy (ERT) is based on the physiological dose of E2 to treat menopausal syndrome and has limited therapeutic efficacy. The efficacy and potential tox...

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Bibliographic Details
Main Authors: Ming Li, Jing Zhang, Wendi Chen, Shuang Liu, Xin Liu, Yunna Ning, Yongzhi Cao, Yueran Zhao
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Journal of Neuroinflammation
Subjects:
17β-Estradiol
Estrogen replacement therapy
Menopausal syndrome
Depression
Microglial
Glycerophospholipid metabolism
Online Access:https://doi.org/10.1186/s12974-023-02889-5

Internet

https://doi.org/10.1186/s12974-023-02889-5

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