MS-Based Approaches Enable the Structural Characterization of Transcription Factor/DNA Response Element Complex

MS-Based Approaches Enable the Structural Characterization of Transcription Factor/DNA Response Element Complex

The limited information available on the structure of complexes involving transcription factors and cognate DNA response elements represents a major obstacle in the quest to understand their mechanism of action at the molecular level. We implemented a concerted structural proteomics approach, which...

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Bibliographic Details
Main Authors: Lukáš Slavata, Josef Chmelík, Daniel Kavan, Růžena Filandrová, Jan Fiala, Michal Rosůlek, Hynek Mrázek, Zdeněk Kukačka, Karel Vališ, Petr Man, Michael Miller, William McIntyre, Daniele Fabris, Petr Novák
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Biomolecules
Subjects:
transcription factor
protein
dna
protein-nucleic acid cross-linking
cross-linking
transplatin
trans-dichlorodiamineplatinum(ii)
hydrogen-deuterium exchange
foxo4
molecular modeling
Online Access:https://www.mdpi.com/2218-273X/9/10/535

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https://www.mdpi.com/2218-273X/9/10/535

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