Calein C, a Sesquiterpene Lactone Isolated From Calea Pinnatifida (Asteraceae), Inhibits Mitotic Progression and Induces Apoptosis in MCF-7 Cells

Calein C, a Sesquiterpene Lactone Isolated From Calea Pinnatifida (Asteraceae), Inhibits Mitotic Progression and Induces Apoptosis in MCF-7 Cells

Breast cancer is the most common cancer in women worldwide. Estrogen receptor-positive (ER+) breast cancer represents approximately 75% of diagnosed cases, while 15–20% of them are triple-negative (TN). Although there have been improvements in the therapeutic approach, the mortality rate remains ele...

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Bibliographic Details
Main Authors: Lhaís Araújo Caldas, Renato O. Horvath, Guilherme Álvaro Ferreira-Silva, Marcelo J. P. Ferreira, Marisa Ionta, Patricia Sartorelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Pharmacology
Subjects:
Asteraceae
Calea pinnatifida
calein C
antimitotic activity
breast cancer
AURKB
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01191/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01191/full

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