The Energy Landscape of Human Serine Racemase

The Energy Landscape of Human Serine Racemase

Human serine racemase is a pyridoxal 5′-phosphate (PLP)-dependent dimeric enzyme that catalyzes the reversible racemization of L-serine and D-serine and their dehydration to pyruvate and ammonia. As D-serine is the co-agonist of the N-methyl-D-aspartate receptors for glutamate, the most abundant exc...

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Bibliographic Details
Main Authors: Samanta Raboni, Marialaura Marchetti, Serena Faggiano, Barbara Campanini, Stefano Bruno, Francesco Marchesani, Marilena Margiotta, Andrea Mozzarelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Molecular Biosciences
Subjects:
pyridoxal 5′-phosphate
enzyme catalysis
allosteric regulation
conformational landscape
D-serine
N-methyl-D-aspartate receptor
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2018.00112/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2018.00112/full

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