Structural insights into human organic cation transporter 1 transport and inhibition

Structural insights into human organic cation transporter 1 transport and inhibition

Abstract The human organic cation transporter 1 (hOCT1), also known as SLC22A1, is integral to hepatic uptake of structurally diversified endogenous and exogenous organic cations, influencing both metabolism and drug pharmacokinetics. hOCT1 has been implicated in the therapeutic dynamics of many dru...

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Bibliographic Details
Main Authors: Shuhao Zhang, Angqi Zhu, Fang Kong, Jianan Chen, Baoliang Lan, Guodong He, Kaixuan Gao, Lili Cheng, Xiaoou Sun, Chuangye Yan, Ligong Chen, Xiangyu Liu
Format: Article
Language:English
Published: Nature Publishing Group 2024-03-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-024-00664-1

Internet

https://doi.org/10.1038/s41421-024-00664-1

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