Structural insights into human organic cation transporter 1 transport and inhibition
Abstract The human organic cation transporter 1 (hOCT1), also known as SLC22A1, is integral to hepatic uptake of structurally diversified endogenous and exogenous organic cations, influencing both metabolism and drug pharmacokinetics. hOCT1 has been implicated in the therapeutic dynamics of many dru...
Main Authors: | Shuhao Zhang, Angqi Zhu, Fang Kong, Jianan Chen, Baoliang Lan, Guodong He, Kaixuan Gao, Lili Cheng, Xiaoou Sun, Chuangye Yan, Ligong Chen, Xiangyu Liu |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2024-03-01
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Series: | Cell Discovery |
Online Access: | https://doi.org/10.1038/s41421-024-00664-1 |
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