The c-Abl-RACK1-FAK signaling axis promotes renal fibrosis in mice through regulating fibroblast-myofibroblast transition

The c-Abl-RACK1-FAK signaling axis promotes renal fibrosis in mice through regulating fibroblast-myofibroblast transition

Abstract Background Renal fibrosis is a prevalent manifestation of chronic kidney disease (CKD), and effective treatments for this disease are currently lacking. Myofibroblasts, which originate from interstitial fibroblasts, aggregate in the renal interstitium, leading to significant accumulation of...

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Bibliographic Details
Main Authors: Qianyi Bao, Anyu Wang, Wenxuan Hong, Yushu Wang, Baojie Li, Lin He, Xiaodong Yuan, Gang Ma
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Cell Communication and Signaling
Subjects:
c-Abl
Renal fibrosis
RACK1
Fibroblast-myofibroblast transition
Focal adhesion
Online Access:https://doi.org/10.1186/s12964-024-01603-z

Internet

https://doi.org/10.1186/s12964-024-01603-z

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