Biophysically inspired model for functionalized nanocarrier adhesion to cell surface: roles of protein expression and mechanical factors

In order to achieve selective targeting of affinity–ligand coated nanoparticles to the target tissue, it is essential to understand the key mechanisms that govern their capture by the target cell. Next-generation pharmacokinetic (PK) models that systematically account for proteomic and mechanical fa...

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Bibliographic Details
Main Authors: N. Ramakrishnan, Richard W. Tourdot, David M. Eckmann, Portonovo S. Ayyaswamy, Vladimir R. Muzykantov, Ravi Radhakrishnan
Format: Article
Language:English
Published: The Royal Society 2016-01-01
Series:Royal Society Open Science
Subjects:
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.160260